Rubio DM, Schoenbaum EE, Lee LS, Schteingart DE, Marantz PR, Anderson KE, et al. Defining translational research: implications for training. Acad Med. 2010;85(3):470–5.
Keramaris NC, Kanakaris NK, Tzioupis C, Kontakis G, Giannoudis PV. Translational research: from benchside to bedside. Injury. 2008;39(6):643–50.
Littman BH, Di Mario L, Plebani M, Marincola FM. What’s next in translational medicine? Clin Sci (Lond). 2007;112(4):217–27.
Marincola FM. Translational Medicine: A two-way road. J Transl Med. 2003;1(1):1.
Davis D, Evans M, Jadad A, Perrier L, Rath D, Ryan D, et al. The case for knowledge translation: shortening the journey from evidence to effect. BMJ. 2003;327(7405):33–5.
Woolf SH. The meaning of translational research and why it matters. JAMA. 2008;299(2):211–3.
National Institutes of Health. Definitions under Subsection 1 (Research Objectives), Section I (Funding Opportunity Description), Part II (Full Text of Announcement), of RFA-RM-07-007: Institutional Clinical and Translational Science Award (U54). http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-07-007.html. Accessed January 4 2015.
Waldman SA, Terzic A. Clinical and translational science: from bench-bedside to global village. Clin Transl Sci. 2010;3(5):254–7.
Kon AA. The Clinical and Translational Science Award (CTSA) Consortium and the translational research model. Am J Bioeth. 2008;8(3):58–60. discussion W1-3.
Butler D. Translational research: crossing the valley of death. Nature. 2008;453(7197):840–2.
Westfall JM, Mold J, Fagnan L. Practice-based research--“Blue Highways” on the NIH roadmap. JAMA. 2007;297(4):403–6.
Brook RH. Medical leadership in an increasingly complex world. JAMA. 2010;304(4):465–6.
Sung NS, Crowley Jr WF, Genel M, Salber P, Sandy L, Sherwood LM, et al. Central challenges facing the national clinical research enterprise. JAMA. 2003;289(10):1278–87.
Canadian Institute of Health Research: Canada's Strategy for Patient-Oriented Research. Improving health Outcomes through evidence-informed care. 2011. www.cihr-irsc.gc.ca/e/44000.html. Accessed January 5 2015.
Reis SE, McDonald MC, Byers SJ. Crossing the research valleys of death: the University of Pittsburgh approach. Clin Transl Sci. 2008;1(1):9–10.
United States Renal Data Service. USRDS 2013 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases; 2013.
Matas AJ, Smith JM, Skeans MA, Thompson B, Gustafson SK, Schnitzler MA, et al. OPTN/SRTR 2012 Annual Data Report: kidney. Am J Transplant. 2014;14 Suppl 1:11–44.
Halawa A. The early diagnosis of acute renal graft dysfunction: a challenge we face. The role of novel biomarkers. Ann Transplant. 2011;16(1):90–8.
Kim SC, Page EK, Knechtle SJ. Urine proteomics in kidney transplantation. Transplant Rev (Orlando). 2014;28(1):15–20.
Bhangoo RS, Hall IE, Reese PP, Parikh CR. Deceased-donor kidney perfusate and urine biomarkers for kidney allograft outcomes: a systematic review. Nephrol Dial Transplant. 2012;27(8):3305–14.
Lesko LJ, Atkinson Jr AJ. Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies. Annu Rev Pharmacol Toxicol. 2001;41:347–66.
Ting YT, Coates PT, Walker RJ, McLellan AD. Urinary tubular biomarkers as potential early predictors of renal allograft rejection. Nephrology (Carlton). 2012;17(1):11–6.
Mishra J, Ma Q, Kelly C, Mitsnefes M, Mori K, Barasch J, et al. Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol. 2006;21(6):856–63.
Lebkowska U, Malyszko J, Lebkowska A, Koc-Zorawska E, Lebkowski W, Malyszko JS, et al. Neutrophil gelatinase-associated lipocalin and cystatin C could predict renal outcome in patients undergoing kidney allograft transplantation: a prospective study. Transplant Proc. 2009;41(1):154–7.
Schaub S, Mayr M, Honger G, Bestland J, Steiger J, Regeniter A, et al. Detection of subclinical tubular injury after renal transplantation: comparison of urine protein analysis with allograft histopathology. Transplantation. 2007;84(1):104–12.
Heyne N, Kemmner S, Schneider C, Nadalin S, Konigsrainer A, Haring HU. Urinary neutrophil gelatinase-associated lipocalin accurately detects acute allograft rejection among other causes of acute kidney injury in renal allograft recipients. Transplantation. 2012;93(12):1252–7.
Blydt-Hansen TD, Sharma A, Gibson IW, Mandal R, Wishart DS. Urinary metabolomics for noninvasive detection of borderline and acute T cell-mediated rejection in children after kidney transplantation. Am J Transplant. 2014;14(10):2339–49.
Puttarajappa C, Shapiro R, Tan HP. Antibody-mediated rejection in kidney transplantation: a review. J Transplant. 2012;2012:193724.
Mauiyyedi S, Colvin RB. Humoral rejection in kidney transplantation: new concepts in diagnosis and treatment. Curr Opin Nephrol Hypertens. 2002;11(6):609–18.
Sureshkumar KK, Hussain SM, Carpenter BJ, Sandroni SE, Marcus RJ. Antibody-mediated rejection following renal transplantation. Expert Opin Pharmacother. 2007;8(7):913–21.
Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant. 2009;9(3):S1–155.
Roberts DM, Jiang SH, Chadban SJ. The treatment of acute antibody-mediated rejection in kidney transplant recipients-a systematic review. Transplantation. 2012;94(8):775–83.
Klein J. George Snell's first foray into the unexplored territory of the major histocompatibility complex. Genetics. 2001;159(2):435–9.
Benacerraf B. Significance and biological function of class II MHC molecules. Rous-Whipple Award lecture 1985. Am J Pathol. 1985;120(3):334–43.
Cecka JM. Current methodologies for detecting sensitization to HLA antigens. Curr Opin Organ Transplant. 2011;16(4):398–403.
Tinckam K. Histocompatibility methods. Transplant Rev (Orlando). 2009;23(2):80–93.
Mulley WR, Kanellis J. Understanding crossmatch testing in organ transplantation: A case-based guide for the general nephrologist. Nephrology (Carlton). 2011;16(2):125–33.
Huber L, Lachmann N, Durr M, Matz M, Liefeldt L, Neumayer HH, et al. Identification and therapeutic management of highly sensitized patients undergoing renal transplantation. Drugs. 2012;72(10):1335–54.
International Histocompatibility Working Group: A brief history of the international histocompatibility workshops. http://www.ihwg.org/about/history.html.
Zachary AA, Montgomery RA, Leffell MS. Defining unacceptable HLA antigens. Curr Opin Organ Transplant. 2008;13(4):405–10.
Jackson AM, Leffell MS, Montgomery RA, Zachary AA. A GPS for finding the route to transplantation for the sensitized patient. Curr Opin Organ Transplant. 2012;17(4):433–9.
Montgomery RA. Renal transplantation across HLA and ABO antibody barriers: integrating paired donation into desensitization protocols. Am J Transplant. 2010;10(3):449–57.
Fuggle SV, Martin S. Tools for human leukocyte antigen antibody detection and their application to transplanting sensitized patients. Transplantation. 2008;86(3):384–90.
Claas FH, Witvliet MD, Duquesnoy RJ, Persijn GG, Doxiadis II. The acceptable mismatch program as a fast tool for highly sensitized patients awaiting a cadaveric kidney transplantation: short waiting time and excellent graft outcome. Transplantation. 2004;78(2):190–3.
Murphey CL, Bingaman AW. Histocompatibility considerations for kidney paired donor exchange programs. Curr Opin Organ Transplant. 2012;17(4):427–32.
Segev DL, Gentry SE, Warren DS, Reeb B, Montgomery RA. Kidney paired donation and optimizing the use of live donor organs. JAMA. 2005;293(15):1883–90.
Chkhotua A. Paired kidney donation: outcomes, limitations, and future perspectives. Transplant Proc. 2012;44(6):1790–2.
Glotz D, Haymann JP, Sansonetti N, Francois A, Menoyo-Calonge V, Bariety J, et al. Suppression of HLA-specific alloantibodies by high-dose intravenous immunoglobulins (IVIg). A potential tool for transplantation of immunized patients. Transplantation. 1993;56(2):335–7.
Tyan DB, Li VA, Czer L, Trento A, Jordan SC. Intravenous immunoglobulin suppression of HLA alloantibody in highly sensitized transplant candidates and transplantation with a histoincompatible organ. Transplantation. 1994;57(4):553–62.
Montgomery RA, Zachary AA, Racusen LC, Leffell MS, King KE, Burdick J, et al. Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients. Transplantation. 2000;70(6):887–95.
Schweitzer EJ, Wilson JS, Fernandez-Vina M, Fox M, Gutierrez M, Wiland A, et al. A high panel-reactive antibody rescue protocol for cross-match-positive live donor kidney transplants. Transplantation. 2000;70(10):1531–6.
Iyer HS, Jackson AM, Zachary AA, Montgomery RA. Transplanting the highly sensitized patient: trials and tribulations. Curr Opin Nephrol Hypertens. 2013;22(6):681–8.
Canadian Transplant Registries. Organ and Tissue Donation and Transplantation. http://www.organsandtissues.ca/s/english-expert/nowhsp-registries. Accessed July 5 2015.
Canadian Blood Services. New program will improve chances of a kidney transplant for hard-to-match patients. https://www.blood.ca/en/media/new-program-will-improve-chances-kidney-transplant-hard-match-patients. Accessed July 5 2015.
Montgomery RA, Lonze BE, King KE, Kraus ES, Kucirka LM, Locke JE, et al. Desensitization in HLA-incompatible kidney recipients and survival. N Engl J Med. 2011;365(4):318–26.
Cole E, Tinckam KJ. Desensitization outcomes: quantifying and questioning. Am J Transplant. 2014;14(7):1475–6.
Solez K, Axelsen RA, Benediktsson H, Burdick JF, Cohen AH, Colvin RB, et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int. 1993;44(2):411–22.
Mengel M, Sis B, Haas M, Colvin RB, Halloran PF, Racusen LC, et al. Banff 2011 Meeting report: new concepts in antibody-mediated rejection. Am J Transplant. 2012;12(3):563–70.
Gupta A, Iveson V, Varagunam M, Bodger S, Sinnott P, Thuraisingham RC. Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplants: are they relevant? Transplantation. 2008;85(8):1200–4.
Ogura K, Terasaki PI, Johnson C, Mendez R, Rosenthal JT, Ettenger R, et al. The significance of a positive flow cytometry crossmatch test in primary kidney transplantation. Transplantation. 1993;56(2):294–8.
Karpinski M, Rush D, Jeffery J, Exner M, Regele H, Dancea S, et al. Flow cytometric crossmatching in primary renal transplant recipients with a negative anti-human globulin enhanced cytotoxicity crossmatch. J Am Soc Nephrol. 2001;12(12):2807–14.
Bryan CF, McDonald SB, Luger AM, Shield CF, Winklhofer FT, Michael Borkon A, et al. Successful renal transplantation despite low levels of donor-specific HLA class I antibody without IVIg or plasmapheresis. Clin Transplant. 2006;20(5):563–70.
van den Berg-Loonen EM, Billen EV, Voorter CE, van Heurn LW, Claas FH, van Hooff JP, et al. Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patients. Transplantation. 2008;85(8):1086–90.
Patel AM, Pancoska C, Mulgaonkar S, Weng FL. Renal transplantation in patients with pre-transplant donor-specific antibodies and negative flow cytometry crossmatches. Am J Transplant. 2007;7(10):2371–7.
Wiebe C, Gibson IW, Blydt-Hansen TD, Karpinski M, Ho J, Storsley LJ, et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant. 2012;12(5):1157–67.
Everly MJ, Rebellato LM, Haisch CE, Ozawa M, Parker K, Briley KP, et al. Incidence and impact of de novo donor-specific alloantibody in primary renal allografts. Transplantation. 2013;95(3):410–7.
Terasaki PI, Ozawa M. Predicting kidney graft failure by HLA antibodies: a prospective trial. Am J Transplant. 2004;4(3):438–43.
Hirai T, Furusawa M, Omoto K, Ishida H, Tanabe K. Analysis of predictive and preventive factors for de novo DSA in kidney transplant recipients. Transplantation. 2014;98(4):443–50.
Archdeacon P, Chan M, Neuland C, Velidedeoglu E, Meyer J, Tracy L, et al. Summary of FDA antibody-mediated rejection workshop. Am J Transplant. 2011;11(5):896–906.
Elwyn G, Crowe S, Fenton M, Firkins L, Versnel J, Walker S, et al. Identifying and prioritizing uncertainties: patient and clinician engagement in the identification of research questions. J Eval Clin Pract. 2010;16(3):627–31.
Brett J, Staniszewska S, Mockford C, Herron-Marx S, Hughes J, Tysall C, et al. Mapping the impact of patient and public involvement on health and social care research: a systematic review. Health Expect. 2014;17(5):637–50.
Chalmers I, Bracken MB, Djulbegovic B, Garattini S, Grant J, Gulmezoglu AM, et al. How to increase value and reduce waste when research priorities are set. Lancet. 2014;383(9912):156–65.
Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet. 2009;374(9683):86–9.
PCORI: Patient-Centered Outcomes Research Institute. http://www.pcori.org/. Accessed January 3, 2015.
INVOLVE: National Institute for Health Research. INVOLVE 2014. http://www.invo.org.uk/. Accessed January 3, 2015.
Jaramillo A, Welch VA, Ueffing E, Gruen RL, Bragge P, Lyddiatt A, et al. Prevention and self-management interventions are top priorities for osteoarthritis systematic reviews. J Clin Epidemiol. 2013;66(5):503–10. e4.
Elberse JE, Pittens CA, de Cock BT, Broerse JE. Patient involvement in a scientific advisory process: setting the research agenda for medical products. Health Policy. 2012;107(2–3):231–42.
The James Lind Alliance. http://www.lindalliance.org/. Accessed January 3, 2015.
Manns B, Hemmelgarn B, Lillie E, Dip SC, Cyr A, Gladish M, et al. Setting research priorities for patients on or nearing dialysis. Clin J Am Soc Nephrol. 2014;9(10):1813–21.
Tong A, Chando S, Crowe S, Manns B, Winkelmayer WC, Hemmelgarn B, et al. Research priority setting in kidney disease: a systematic review. Am J Kidney Dis. 2015;65(5):674–83.
Tong A, Sainsbury P, Carter SM, Hall B, Harris DC, Walker RG, et al. Patients’ priorities for health research: focus group study of patients with chronic kidney disease. Nephrol Dial Transplant. 2008;23(10):3206–14.
Bartosh SM, Ryckman FC, Shaddy R, Michaels MG, Platt JL, Sweet SC. A national conference to determine research priorities in pediatric solid organ transplantation. Pediatr Transplant. 2008;12(2):153–66.
Opelz G, Döhler B. HLA matching and kidney transplantation: beyond graft survival. Clin Transpl. 2013;121–6.
Patrick D, Guyatt GH, Acquadro C. Chapter 17: Patient-reported outcomes. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. http://www.cochrane-handbook.org.
Denhaerynck K, Dobbels F, Cleemput I, Desmyttere A, Schafer-Keller P, Schaub S, et al. Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: a literature review. Transpl Int. 2005;18(10):1121–33.
Pinsky BW, Takemoto SK, Lentine KL, Burroughs TE, Schnitzler MA, Salvalaggio PR. Transplant outcomes and economic costs associated with patient noncompliance to immunosuppression. Am J Transplant. 2009;9(11):2597–606.
Greenstein S, Siegal B. Compliance and noncompliance in patients with a functioning renal transplant: a multicenter study. Transplantation. 1998;66(12):1718–26.
Tong A, Howell M, Wong G, Webster AC, Howard K, Craig JC. The perspectives of kidney transplant recipients on medicine taking: a systematic review of qualitative studies. Nephrol Dial Transplant. 2011;26(1):344–54.
Gordon EJ, Gallant M, Sehgal AR, Conti D, Siminoff LA. Medication-taking among adult renal transplant recipients: barriers and strategies. Transpl Int. 2009;22(5):534–45.
Reimer J, Franke GH, Philipp T, Heemann U. Quality of life in kidney recipients: comparison of tacrolimus and cyclosporine-microemulsion. Clin Transplant. 2002;16(1):48–54.
Hathaway D, Winsett R, Prendergast M, Subaiya I. The first report from the patient outcomes registry for transplant effects on life (PORTEL): differences in side-effects and quality of life by organ type, time since transplant and immunosuppressive regimens. Clin Transplant. 2003;17(3):183–94.
De Geest S, Schafer-Keller P, Denhaerynck K, Thannberger N, Kofer S, Bock A, et al. Supporting medication adherence in renal transplantation (SMART): a pilot RCT to improve adherence to immunosuppressive regimens. Clin Transplant. 2006;20(3):359–68.
Chisholm MA, Mulloy LL, Jagadeesan M, DiPiro JT. Impact of clinical pharmacy services on renal transplant patients' compliance with immunosuppressive medications. Clin Transplant. 2001;15(5):330–6.
Kasbia GS, Farragher J, Kim SJ, Famure O, Jassal SV. A cross-sectional study examining the functional independence of elderly individuals with a functioning kidney transplant. Transplantation. 2014;98(8):864–70.
Humar A, Denny R, Matas AJ, Najarian JS. Graft and quality of life outcomes in older recipients of a kidney transplant. Exp Clin Transplant. 2003;1(2):69–72.
Cornella C, Brustia M, Lazzarich E, Cofano F, Ceruso A, Barbe MC, et al. Quality of life in renal transplant patients over 60 years of age. Transplant Proc. 2008;40(6):1865–6.
Laupacis A, Keown P, Pus N, Krueger H, Ferguson B, Wong C, et al. A study of the quality of life and cost-utility of renal transplantation. Kidney Int. 1996;50(1):235–42.
Bachmann S, Finger C, Huss A, Egger M, Stuck AE, Clough-Gorr KM. Inpatient rehabilitation specifically designed for geriatric patients: systematic review and meta-analysis of randomised controlled trials. BMJ. 2010;340:c1718.
Chang JT, Morton SC, Rubenstein LZ, Mojica WA, Maglione M, Suttorp MJ, et al. Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials. BMJ. 2004;328(7441):680.
Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A program to prevent functional decline in physically frail, elderly persons who live at home. N Engl J Med. 2002;347(14):1068–74.
Cheema BS, Singh MA. Exercise training in patients receiving maintenance hemodialysis: a systematic review of clinical trials. Am J Nephrol. 2005;25(4):352–64.
Forrest GP. Inpatient rehabilitation of patients requiring hemodialysis. Arch Phys Med Rehabil. 2004;85(1):51–3.
Howell MR, Wong G, Tong A, Tan HT, Craig J, Howard K. Quality of life outcomes reported in randomised controlled trials of immunosuppressive drug regimens in kidney transplantation: a systematic review. Transplantation. 2012;94(10S):182.
Valderas JM, Kotzeva A, Espallargues M, Guyatt G, Ferrans CE, Halyard MY, et al. The impact of measuring patient-reported outcomes in clinical practice: a systematic review of the literature. Qual Life Res. 2008;17(2):179–93.