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Table 2 Mayo Clinic proposed diagnostic criteria of IgG4-TIN

From: Recognizing IgG4-related tubulointerstitial nephritis

TIN IgG4-RKD can be confirmed by the presence of tubulointerstitial nephritis with >10 IgG4+ plasma cells/hpf in the most concentrated field, plus at least one of the following:
• Histology:
  ο Tubular basement membrane immune complex deposits by immunofluorescence, immunohistochemistry, and/or electron microscopy
• Imaging:
  ο Small peripheral low-attenuation cortical nodules, round or wedge-shaped lesions, or diffuse patchy involvement
• Serology:
  ο Elevated serum IgG4 or total IgG level
• Other organ involvement such as the following:
  ο AIP, sclerosing cholangitis, inflammatory masses of any origin, sialadenitis, inflammatory aortic aneurysm, lung involvement, retroperitoneal fibrosis