Fig. 2

Repeated EOC CM injections lead to continued protection against CKD-associated renal fibrosis. Kidney sections were immunolabeled for collagen IV. a Representative glomerular images. Original magnification ×400. b Representative tubulointerstitial images. Original magnification ×160. c Quantification of glomerular type IV collagen positivity. Thirty randomly selected glomeruli cut through the macula densa were sampled per kidney section (n = 11, No Therapy; n = 8, Initial Therapy Only; n = 7, Repeat Therapy). d Quantification of tubulointerstitial type IV collagen positivity. Ten randomly selected, non-overlapping ×20 fields were sampled per kidney section (n = 11, No Therapy; n = 8, Initial Therapy Only; n = 7, Repeat Therapy). *p < 0.05 vs. SNX animals receiving No Therapy. AU arbitrary units