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Table 1 Future opportunities for research translation

From: Bridging the gap: a Canadian perspective on translational kidney research

Topic of research Opportunities for research translation Translational chasm
Discovery and characterization of novel ciliopathy genes • Genetic counseling for families. Moving from basic science to a proposed human/clinical application (T1)
• Accurate diagnosis of a specific condition using genetic sequencing.
• Although controversial, there is the potential for pre-implantation genetic screening.
• Potential for the development of targeted therapies (genetic disorders and acute kidney injury).
Cell based therapies for kidney disease • Potential for a novel therapy for the treatment of progressive CKD. Design of a randomized controlled trial to test the infusion of EOC derived factors vs. standard care for the treatment of CKD. Moving from basic science to a proposed human application (T1) and now towards a proven clinical application (T2)
Acute kidney injury in the renal transplant population • Development of a predictive model that would predict the risk of graft loss or death following an episode of AKI. Moving a clinical research finding into clinical practice (T3)
• Potential to use the developed predictive model to identify high risk patients for the study of mechanisms of graft loss. Mechanistic studies could lead to targeted therapies for testing in randomized controlled trials. Moving a clinical research finding back to basic science and towards a proposed human application (T1)
Risk based care for chronic kidney disease • Dialysis access planning pathways that incorporate the KFRE. Moving a clinical research finding into clinical practice and performing practice based research (T3)
• Cost utility analyses of referral and treatment pathways that incorporate the KFRE.
• Evaluation of the KFRE against novel biomarkers for CKD progression.