Articles

Canadian Organ Replacement Register (CORR): reflecting the past and embracing the future

The Canadian Organ Replacement Register (CORR) is the only Canadian information system on kidney and extra-kidney organ failure and transplantation in Canada. CORR’s mandate is to record and analyze the level ...

Authors: Louise M Moist, Stanley Fenton, Joseph S Kim, John S Gill, Frank Ivis, Eric de Sa, Juliana Wu, Ahmed A Al-Jaishi, Manish M Sood, Scott Klarenbach, Brenda R Hemmelgarn and Joanne E Kappel

Is it ethical to prescribe generic immunosuppressive drugs to renal transplant patients?

This review was conducted to determine the ethical acceptability of prescribing generic immunosuppressive drugs to renal transplant patients.

Authors: Julie Allard and Marie-Chantal Fortin

The three-year incidence of major hemorrhage among older adults initiating chronic dialysis

For those who initiate chronic dialysis, knowing what proportion will experience 3-year outcomes of hemorrhage with hospitalization informs patient prognosis, disease impact, and the planning of trials and pro...

Authors: Manish M Sood, Sarah E Bota, Eric McArthur, Moira K Kapral, Navdeep Tangri, Greg Knoll, Deborah Zimmerman and Amit X Garg

Bridging the gap: a Canadian perspective on translational kidney research

Chronic kidney disease affects approximately 3 million Canadians. Ongoing investment in high quality kidney research is needed to improve the care of patients with kidney disease. The barriers to translating s...

Authors: Amber O Molnar, Darren A Yuen, Navdeep Tangri and Victor L Jensen

Improving prevention, early recognition and management of acute kidney injury after major surgery: results of a planning meeting with multidisciplinary stakeholders

Acute kidney injury (AKI) is common after major surgery, and is associated with morbidity, mortality, increased length of hospital stay, and high health care costs. Although recent guidelines for AKI provide r...

Authors: Matthew T James, Elijah Dixon, Derek J Roberts, Rebecca Barry, Carlee Balint, Aleem Bharwani, William Don Buie, Tomas Godinez, Brenda R Hemmelgarn, John B Kortbeek, Braden J Manns, Andria Marin, Nairne Scott-Douglas, Henry Tom Stelfox and Neesh Pannu

Brief communication: patient satisfaction with the use of tablet computers: a pilot study in two outpatient home dialysis clinics

Electronic capture of patients’ reports of their health is significant in clinical nephrology research because health-related quality of life (HRQOL) for patients with end-stage renal disease is compromised an...

Authors: Kara Schick-Makaroff and Anita Molzahn

Fluid balance, change in serum creatinine and urine output as markers of acute kidney injury post cardiac surgery: an observational study

Acute kidney injury (AKI) is defined as oliguria or rise in serum creatinine but oliguria alone as a diagnostic criterion may over-diagnose AKI.

Authors: Katrina Chau, Travis Schisler, Lee Er, Dharmvir Jaswal, Christopher Cheung, Amanda Israel, John Bowering and Adeera Levin

The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) Project: overview of design and methods

Nephrotic syndrome is a commonly acquired kidney disease in children that causes significant morbidity due to recurrent episodes of heavy proteinuria. The management of childhood nephrotic syndrome is known to...

Authors: Susan Samuel, Shannon Scott, Catherine Morgan, Allison Dart, Cherry Mammen, Rulan Parekh, Alberto Nettel-Aguirre, Allison Eddy, Rachel Flynn, Maury Pinsk, Andrew Wade, Steven Arora, Geneviève Benoit, Martin Bitzan, Robin Erickson, Janusz Feber…

Cardiac biomarkers and health-related quality of life in new hemodialysis patients without symptomatic cardiac disease

Health Related Quality of Life (HRQOL) is impaired in hemodialysis patients and cardiac biomarkers are elevated, but their relationship is uncertain.

Authors: Christopher E Williams, Bryan M Curtis, Edward W Randell, Robert N Foley and Patrick S Parfrey

Risk factors associated with hemodialysis central venous catheter malfunction; a retrospective analysis of a randomized controlled trial

We previously reported a reduction in central venous catheter (CVC) malfunction when using once-weekly recombinant tissue-plasminogen activator (rt-PA) as a locking solution, compared with thrice-weekly heparin.

Authors: David R Ward, Louise M Moist, Jennifer M MacRae, Nairne Scott-Douglas, Jianguo Zhang, Marcello Tonelli, Charmaine E Lok, Steven D Soroka and Brenda R Hemmelgarn

Cost analysis of in-centre nocturnal compared with conventional hemodialysis

Provision of in-centre nocturnal hemodialysis (ICNHD; 6–8 hours thrice weekly) is associated with health benefits, but the economic implications of providing this treatment are unclear.

Authors: Ben Wong, Mark Courtney, Robert P Pauly, Kailash Jindal and Scott Klarenbach

Assessment of potential biomarkers of subclinical vitamin K deficiency in patients with end-stage kidney disease

A significant proportion of hemodialysis patients have functional, but modifiable, vitamin K deficiency.

Authors: Meghan J Elliott, Sarah L Booth, Wilma M Hopman and Rachel M Holden

Estimation of total glomerular number using an integrated disector method in embryonic and postnatal kidneys

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are a polymorphic group of clinical disorders comprising the major cause of renal failure in children. Included within CAKUT is a wide spectrum of d...

Authors: Michel G Arsenault, Yuan Miao, Kathleen Jones, David Sims, Jonathan Spears, Glenda M Wright and Sunny Hartwig

Programmatic variation in home hemodialysis in Canada: results from a nationwide survey of practice patterns

Over 40% of patients with end stage renal disease in the United States were treated with home hemodialysis (HHD) in the early 1970’s. However, this number declined rapidly over the ensuing decades so that the ...

Authors: Robert P Pauly, Paul Komenda, Christopher T Chan, Michael Copland, Azim Gangji, David Hirsch, Robert Lindsay, Martin MacKinnon, Jennifer M MacRae, Philip McFarlane, Gihad Nesrallah, Andreas Pierratos, Martin Plaisance, Frances Reintjes, Jean-Philippe Rioux, John Shik…

Mortality risk for women on chronic hemodialysis differs by age

Previous reports have demonstrated similar survival for men and women on hemodialysis, despite women’s increased survival in the general population.

Authors: Manish M Sood, Claudio Rigatto, Paul Komenda, Julie Mojica and Navdeep Tangri

Incentives and organ donation: what’s (really) legal in Canada?

To date, there has been little analysis of the degree to which emerging incentive initiatives are permissible under Canadian law. The purpose of this review is to examine the relevant law – including legislati...

Authors: Timothy Caulfield, Erin Nelson, Brice Goldfeldt and Scott Klarenbach

Is the Canadian legal framework too restrictive and based on false premises?

Authors: Marie-Chantal Fortin

Evaluating the implementation strategy for estimated glomerular filtration rate reporting in Manitoba: the effect on referral numbers, wait times, and appropriateness of consults

Chronic kidney disease screening using estimated glomerular filtration rate (eGFR) reporting is standard in many regions. With its implementation, many centres have had higher referral rates and increased wait...

Authors: Jay Hingwala, Sandip Bhangoo, Brett Hiebert, Manish M Sood, Claudio Rigatto, Navdeep Tangri and Paul Komenda

Foundations and principles of the Canadian living donor paired exchange program

Kidney paired donation (KPD) remains an important strategy to facilitate transplantation in patients who have a healthy and willing donor, but are unable to proceed with directed donation due to either ABO inc...

Authors: Shafi Malik and Edward Cole

The Canadian Society of Nephrology methods in developing and adapting clinical practice guidelines: a review

The Canadian Society of Nephrology (CSN) was established to promote the highest quality of care for patients with renal diseases and to encourage research related to the kidney and its disorders. The CSN Clini...

Authors: Reem A Mustafa, Adeera Levin, Ayub Akbari, Bethany J Foster, Deborah Zimmerman, Gihad E Nesrallah, Greg A Knoll, Jean-Philippe Rioux, Jim Barton, Marcel Ruzicka, Norman Muirhead, Louise Moist, Neesh Pannu, Phil McFarlane, Scott Klarenbach, Susan Samuel…

An assessment of dialysis provider’s attitudes towards timing of dialysis initiation in Canada

Physicians’ perceptions and opinions may influence when to initiate dialysis.

Authors: Bikaramjit S Mann, Braden J Manns, Allison Dart, Joanne Kappel, Anita Molzahn, David Naimark, Sharon J Nessim, Steven Soroka, Michael Zappitelli and Manish M Sood

Views of Canadian patients on or nearing dialysis and their caregivers: a thematic analysis

Quality of life of patients receiving dialysis has been rated as poor.

Authors: Lianne Barnieh, Kathryn King-Shier, Brenda Hemmelgarn, Andreas Laupacis, Liam Manns and Braden Manns

Establishing a national knowledge translation and generation network in kidney disease: the CAnadian KidNey KNowledge TraNslation and GEneration NeTwork

Patients with chronic kidney disease (CKD) do not always receive care consistent with guidelines, in part due to complexities in CKD management, lack of randomized trial data to inform care, and a failure to d...

Authors: Braden Manns, Brendan Barrett, Michael Evans, Amit Garg, Brenda Hemmelgarn, Joanne Kappel, Scott Klarenbach, Francois Madore, Patrick Parfrey, Susan Samuel, Steven Soroka, Rita Suri, Marcello Tonelli, Ron Wald, Michael Walsh and Michael Zappitelli

Canadian Journal of Kidney Health and Disease: a unique launch of a unique journal

Usually inaugural editorials are written by the Editor-in-Chief to describe the scope and vision for the journal to potential authors and readers. This editorial is written by the Editor-in-Chief, the Deputy E...

Authors: Adeera Levin, Catherine M Clase, Manish M Sood, Elizabeth Dicks, Marie-Chantal Fortin, Sunny Hartwig, Rachel Holden, Jean-Philippe Lafrance, Anita Molzahn, Norman Rosenblum, Susan Samuel and Steven Soroka