|
ESA exposure (%)
|
4 (3)
|
128 (97)
| |
–
|
–
|
<0.0001
|
|
NODAT Yes (%)
|
–
|
–
| |
4 (8)
|
48 (92)
|
–
|
|
Age at transplant (years)
|
58.2 ± 11.6
|
50.7 ± 13.4
|
0.0001
|
51.8 ± 13.8
|
51.4 ± 13.2
|
0.51
|
|
Male (%)
|
33 (63)
|
248 (62)
|
0.89
|
68 (51)
|
213 (67)
|
0.002
|
|
Donor source deceased (%)
|
33 (63)
|
187 (47)
|
0.005
|
78/ (60)
|
142 (45)
|
0.005
|
|
Body mass index (BMI)
|
26.9 ± 6.5
|
26.2 ± 5
|
0.43
|
25.8 ± 4.9
|
26.5 ± 5.3
|
0.21
|
|
Hepatitis C+ yes (%)
|
0 (0)
|
4 (1)
|
0.76
|
1 (0.7)
|
3(0.9)
|
0.63
|
|
Acute rejection (AR) yes (%)
|
2 (4)
|
26 (6)
|
0.35
|
11 (8)
|
17(5)
|
0.22
|
|
Cause end-stage renal disease:
| | | | | | |
|
Hypertension
|
11
|
33
|
0.003
|
11
|
33
|
0.51
|
|
Glomerulonephritis
|
25
|
196
|
0.88
|
70
|
151
|
0.27
|
|
Polycystic kidney disease
|
6
|
55
|
0.65
|
16
|
45
|
0.57
|
|
Interstitial nephritis
|
2
|
46
|
0.06
|
14
|
34
|
0.98
|
|
Obstructive uropathy
|
1
|
6
|
0.57
|
1
|
6
|
0.34
|
|
Other
|
7
|
63
|
0.66
|
20
|
50
|
0.88
|
|
Blood glucose at start of ESA (N = 13/N = 129)
|
7.3 ± 2
|
6.2 ± 1.4
|
0.04
|
–
|
–
|
–
|
|
Blood glucose at the end of ESA (N = 13/N = 129)
|
5.3 ± 1.5
|
5.7 ± 1.2
|
0.08
|
–
|
–
|
–
|
|
Tacrolimus IR yes (%)
|
40 (77)
|
311 (78)
|
0.86
|
104 (79)
|
247 (77)
|
0.75
|
|
Cyclosporine yes (%)
|
9 (17)
|
55 (14)
|
0.49
|
11 (8)
|
53 (16)
|
0.02
|
|
Tacrolimus ER (Advagraf) yes (%)
|
8 (15)
|
74 (18.5)
|
0.67
|
20 (15)
|
61 (19)
|
0.31
|
|
Prednisone yes (%)
|
50 (96)
|
345 (86)
|
0.02
|
121 (92)
|
274 (86)
|
0.09
|
|
Creatinine (SCr) at initial hospital discharge (umol/L)
|
162.8 ± 110.2
|
180.4 ± 147.7
|
0.32
|
225.1 ± 188.3
|
157.5 ± 113
|
0.0002
|
|
SCr at 3 months (umol/L)
|
114.3 ± 35.2
|
127.2 ± 43.6
|
0.05
|
136.4 ± 56.5
|
121.1 ± 34.4
|
0.005
|
|
SCr at 6 months (umol/L)
|
119.3 ± 36.7
|
128.9 ± 49.8
|
0.10
|
142.9 ± 70.3
|
121.1 ± 32.6
|
0.001
|
|
Hemoglobin (Hb) at discharge
|
98 ± 17.8
|
98.7 ± 14.9
|
0.76
|
93.8 ± 14.8
|
100.8 ± 15
|
<.0001
|
|
Hb at 3 months
|
120.8 ± 16.8
|
123 ± 17.2
|
0.41
|
117.7 ± 16.2
|
125 ± 16.9
|
<.0001
|
|
Hb at 6 months
|
131.6 ± 14.4
|
128.5 ± 18.2
|
0.25
|
123.4 ± 17.3
|
131.3 ± 17.5
|
<.0001
|
|
Random blood glucose (RBG) at discharge
|
7.1 ± 2.1
|
5.8 ± 1.7
|
<.0001
|
6 ± 1.8
|
6 ± 1.8
|
0.93
|
|
RBG at 3 months
|
7.7 ± 2.3
|
5.9 ± 1.3
|
<.0001
|
6.2 ± 1.6
|
6.1 ± 1.7
|
0.65
|
|
RBG at 6 months
|
6.9 ± 1.6
|
5.6 ± 0.9
|
<.0001
|
5.5 ± 1
|
5.8 ± 1.2
|
0.01
|
