Comparative effectiveness of home dialysis therapies: a matched cohort study

Table 3 Hazard ratios for all-cause mortality in primary and sensitivity analyses

Group	Number of patients	Number of events^a	Deaths per 100 person-years	HR (95 % CI)^b	P value
Main analysis
Matched sample, intent-to-treat analysis
PD patients (referent)	2668	868	16.71	1	<0.001
Daily HD patients	2668	625	12.56	0.75 (0.68–0.82)
Additional analyses
Unmatched sample, intent-to-treat analysis, inverse probability of treatment weighting
PD patients (referent)	74,922	24,638	14.99	1	<0.001
Daily HD patients	3142	719	12.20	0.84 (0.82–0.86)
Matched sample, as-treated analysis (90-day follow-up after modality switches)
PD patients (referent)	2668	410	13.33	1	0.005
Daily HD patients	2668	496	11.52	0.83 (0.74–0.95)
Unmatched sample, intent-to-treat analysis, adjusting for propensity score
PD patients (referent)	74,922	24,638	14.99	1	0.002
Daily HD patients	3142	719	12.20	0.89 (0.82–0.96)
Matched sample, intent-to-treat analysis, index date within 12 months of ESRD date
PD patients (referent)	877	280	17.04	1	<0.001
Daily HD patients	877	174	11.03	0.65 (0.54–0.78)

^aFollow-up truncated at 5 years.
^bHazard ratio was derived from Cox proportional hazards model including robust variance estimator to account for within-pair correlation

ISSN: 2054-3581