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Table 2 Odds of higher interest in genetic testing by socio-demographic and clinical factors among 320 INSIGHT participants

From: Parental attitudes to genetic testing differ by ethnicity and immigration in childhood nephrotic syndrome: a cross-sectional study

  Parental interest in genetic testing
Unadjusted Adjusted model 1 Adjusted model 2
OR [95 % CI] OR [95 % CI] OR [95 % CI]
Parent age (per 5 years) 1.31* [1.05–1.60] 1.30 [0.92–1.84] 1.29 [0.93–1.79]
Parent education level       
 Primary/high school ref ref ref
 University/graduate 1.24 [0.64–2.42] 1.19 [0.54–2.60] 1.02 [0.47–2.20]
Parent self-reported ethnicity       
 European ref ref   
 South Asian 0.27* [0.12–0.59] 0.32* [0.13–0.82]   
 East/Southeast Asian 0.27* [0.09–0.79] 0.22* [0.07–0.72]   
 Othera 1.22 [0.36–4.06] 1.81 [0.35–9.22]   
Parent immigration status       
 Born in Canada ref    ref
 Born outside of Canada 0.23** [0.11–0.52]    0.34* [0.14–0.83]
Language spoken at home       
 English ref     
 English and other language 0.38 [0.14–1.06]     
 Other language only 0.38* [0.19–0.74]     
Duration of time in Canada       
 >10 years ref     
 ≤10 years 0.58 [0.27–1.23]     
Female child 1.12 [0.59–2.11]     
Child age (per year) 1.07* [1.01–1.14] 1.01 [0.92–1.11] 1.02 [0.93–1.12]
Family history of kidney disease 1.66 [0.81–3.40]     
Family history of CVDb, diabetes, or hypertension 1.94 [0.93–4.06]     
Initial steroid resistance 0.71 [0.23–2.23]     
  1. Age is calculated at time of questionnaire completion. Model 1—parent ethnicity adjusted for parent age and education level, child age and sex, initial steroid resistance, and duration of time in Canada. Model 2—parent immigration status adjusted for parent age and education level, child age and sex, initial steroid resistance, and duration of time in Canada
  2. *p ≤ 0.05; **p < 0.001
  3. aOther includes Middle Eastern, West Indian/Caribbean and African, Mexican/South and Central American, Aboriginal, and Multi-ethnic
  4. bCardiovascular disease