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Table 2 Odds of higher interest in genetic testing by socio-demographic and clinical factors among 320 INSIGHT participants

From: Parental attitudes to genetic testing differ by ethnicity and immigration in childhood nephrotic syndrome: a cross-sectional study

 

Parental interest in genetic testing

Unadjusted

Adjusted model 1

Adjusted model 2

OR

[95 % CI]

OR

[95 % CI]

OR

[95 % CI]

Parent age (per 5 years)

1.31*

[1.05–1.60]

1.30

[0.92–1.84]

1.29

[0.93–1.79]

Parent education level

      

 Primary/high school

ref

ref

ref

 University/graduate

1.24

[0.64–2.42]

1.19

[0.54–2.60]

1.02

[0.47–2.20]

Parent self-reported ethnicity

      

 European

ref

ref

  

 South Asian

0.27*

[0.12–0.59]

0.32*

[0.13–0.82]

  

 East/Southeast Asian

0.27*

[0.09–0.79]

0.22*

[0.07–0.72]

  

 Othera

1.22

[0.36–4.06]

1.81

[0.35–9.22]

  

Parent immigration status

      

 Born in Canada

ref

  

ref

 Born outside of Canada

0.23**

[0.11–0.52]

  

0.34*

[0.14–0.83]

Language spoken at home

      

 English

ref

    

 English and other language

0.38

[0.14–1.06]

    

 Other language only

0.38*

[0.19–0.74]

    

Duration of time in Canada

      

 >10 years

ref

    

 ≤10 years

0.58

[0.27–1.23]

    

Female child

1.12

[0.59–2.11]

    

Child age (per year)

1.07*

[1.01–1.14]

1.01

[0.92–1.11]

1.02

[0.93–1.12]

Family history of kidney disease

1.66

[0.81–3.40]

    

Family history of CVDb, diabetes, or hypertension

1.94

[0.93–4.06]

    

Initial steroid resistance

0.71

[0.23–2.23]

    
  1. Age is calculated at time of questionnaire completion. Model 1—parent ethnicity adjusted for parent age and education level, child age and sex, initial steroid resistance, and duration of time in Canada. Model 2—parent immigration status adjusted for parent age and education level, child age and sex, initial steroid resistance, and duration of time in Canada
  2. *p ≤ 0.05; **p < 0.001
  3. aOther includes Middle Eastern, West Indian/Caribbean and African, Mexican/South and Central American, Aboriginal, and Multi-ethnic
  4. bCardiovascular disease