|
Control arm CAC progression rate
|
Relative risk reduction
|
Phylloquinone arm progression rate
|
Sample size per arm for 80% power
|
|---|
|
80
|
20%
|
64%
|
123
|
|
70
|
20%
|
56%
|
186
|
|
60
|
20%
|
48%
|
270
|
|
50
|
20%
|
40%
|
388
|
|
80
|
25%
|
60%
|
80
|
|
70
|
25%
|
53%
|
121
|
|
60
|
25%
|
45%
|
173
|
|
50
|
25%
|
38%
|
247
|
|
RRR = Relative risk reduction
| | |
- Estimate of the power for testing the effect of the intervention. The effect sizes are described in terms of relative risk reduction for a > 15% increase in CAC score over baseline in 12 months. The bolded row indicates estimates utilized for sample size calculation for the iPACK-HD trial.
