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Table 1 Patient serum and urine parameters at presentation and last follow-up

From: PTHrP-related Hypercalcaemia in Infancy and Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

Serum or urine parameter At presentation At last follow-up Age-appropriate reference interval
Serum creatinine 63 μmol/L 34 μmol/L <53 μmol/L
Cystatin C eGFR 51 mL/min/1.73 m2 89 mL/min/1.73 m2 >90 mL/min/1.73 m2
Serum calcium 4.98 mmol/L 2.67 mmol/L 2.24-2.74 mmol/L
Serum urea 13.7 mmol/L 6.1 mmol/L <8.0 mmol/L
Serum bicarbonate 15 mmol/L 21 mmol/L 22-29 mmol/L
Serum sodium 134 mmol/L 139 mmol/L 135-145 mmol/L
Fractional sodium excretion 20.06% n.d. N/A
Urine calcium 2.93 mmol/L 1.45 mmol/L N/A
Uca/cr ratio 9.8 mmol/mmol 0.822 mmol/mmol <1 at 6 months, <0.6 at 2 years
PTH 0.4 pmol/L 3.3 pmol/L 1.6-6.9 pmol/L
25-vitamin D 140 nmol/L 94 nmol/L 75-225 nmol/L
1,25 dihydroxy-vitamin D <10 pmol/L n.d. 39-193 pmol/L
Vitamin A 0.7 μmol/L n.d. 1.2-2.8 μmol/L
Alkaline phosphatase 206 U/L 296 U/L <449 U/L
PTHrP 3.8 pmol/L n.d. <2 pmol/L
Phosphate 0.83 mmol/L 1.83 mmol/L 1.3-2.6 mmol/L