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Table 5 Multilevel logistic regression examining the association between renin angiotensin system antagonists and acute kidney injury by evidence-based indication (model 1 shows the effects of renin angiotensin system antagonists with no adjustment, model 2 is adjusted for age and gender)

From: Acute kidney injury: an acceptable risk of treatment with renin-angiotensin system blockade in primary care?

Model

Interaction p-value

Indication

Odds ratio (95% CI)

P-value

No AKI versus AKI

Model 1

<0.001

No

1.94 (1.72, 2.19)

<0.001

  

Yes

1.14 (1.04, 1.24)

0.004

Model 2

0.003

No

1.52 (1.34, 1.72)

<0.001

  

Yes

1.22 (1.12, 1.33)

<0.001

No AKI/AKIN1 versus AKIN2/AKIN3

Model 1

<0.001

No

2.31 (1.61, 3.30)

<0.001

  

Yes

0.98 (0.74, 1.30)

0.90

Model 2

0.005

No

2.04 (1.41, 2.94)

<0.001

  

Yes

1.05 (0.79, 1.39)

0.73

  1. AKI (acute kidney injury), AKIN1 (acute kidney injury network stage 1), AKIN2 (acute kidney injury network stage 2), AKIN3 (acute kidney injury network stage 3).