Table 3 Multilevel logistic regression examining the association between renin angiotensin system antagonists and other variables with AKIN2/AKIN3 compared with noAKI/AKIN1

Model 1

ACE/ARB

No

1

<0.001

Yes

1.73 (1.41, 2.11)

Model 2

ACE/ARB

No

1

<0.001

Yes

1.62 (1.31, 1.99)

Age ^(*)

Linear term

0.44 (0.30, 0.67)

<0.001

Quadratic term

1.09 (1.06, 1.13)

Sex

Female

1

0.21

Male

1.15 (0.92, 1.43)

Model 3

ACE/ARB

No

1

0.85

Yes

1.02 (0.81, 1.29)

Age ^(*)

Linear term

0.43 (0.27, 0.68)

<0.001

Quadratic term

1.08 (1.04, 1.12)

Sex

Female

1

0.34

Male

1.12 (0.89, 1.40)

Hypertension

1.87 (1.27, 2.74)

0.001

Diabetes

1.69 (1.33, 2.15)

<0.001

IHD

0.96 (0.73, 1.25)

0.75

Heart Failure

2.09 (1.44, 3.05)

<0.001

Systolic BP < 100

4.37 (3.18, 5.99)

<0.001

CKD stage

1

1

<0.001

2

1.32 (1.01, 1.71)

3

1.78 (1.29, 2.45)

4

2.39 (1.47, 3.91)

Diuretic

1.66 (1.34, 2.06)

<0.001

Model 4

ACE/ARB

No

1

0.17

Yes

0.83 (0.63, 1.09)

Age ^(*)

Linear term

0.47 (0.24, 0.93)

<0.001

Quadratic term

1.07 (1.02, 1.12)

Sex

Female

1

0.79

Male

1.06 (0.81, 1.40)

Hypertension

2.17 (1.29, 3.65)

0.003

Diabetes

1.32 (0.99, 1.74)

0.06

IHD

1.07 (0.78, 1.46)

0.69

Heart Failure

1.66 (1.07, 2.56)

0.02

Systolic BP < 100

4.34 (2.96, 6.36)

<0.001

CKD stage

1

1

0.47

2

1.16 (0.85, 1.56)

3

1.31 (0.89, 1.92)

4

1.38 (0.76, 2.45)

Diuretic

1.56 (1.20, 2.02)

0.001

Proteinuria

None

1

<0.001

Moderate

1.62 (1.21, 2.17)

Severe

3.43 (2.22, 5.29)