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Table 3 Stratum-specific prevalence of chronic kidney disease, León, Nicaragua by demographic characteristics and potential risk factors

From: A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua

 

N (%)

Percent missing

Stratum-specific prevalence (95% CI) *

p-value §

0 < =GFR < 60

60 < =GFR < 90

GFR= > 90

N = 208

N = 493

N = 1574

GFR data

N = 218

Mean eGFR ± SD

2493

8.7

39 ± 15

78 ± 8

121 ± 20

 

Demographic Characteristics

     

Sex

      

  Female

1434 (58)

7.7

5.8 (4.6, 7.1)

19.9 (17.8, 22.1)

74.2 (71.9, 76.6)

<.0001

 Male

1054 (42)

9.8

13.8 (11.6, 16)

24.1 (21.4, 26.8)

62.1 (59.1, 65.2)

 

Age (continuous)

 

2493(100)

1.6

51.4 ± 11.8

45.3 ± 11.7

36.2 ± 11.4

 

Age (categorical)

 18-29

595 (24)

7.9

1.6 (0.6, 2.7)

9.1 (6.7, 11.5)

89.2 (86.6, 91.8)

 

 30-39

781 (32)

6.8

3.8 (2.4, 5.2)

14.6 (12, 17.1)

81.6 (78.8, 84.4)

<.0001

 40-49

489 (20)

8.2

8.9 (6.3, 11.5)

34.1 (29.7, 38.5)

57.0 (52.4, 61.6)

 

 50-59

361 (15)

6.1

20.1 (15.8, 24.3)

35.1 (30, 40.2)

44.8 (39.5, 50.1)

 

 60-70

227 (9)

7.0

29.9 (23.7, 36)

30.8 (24.6, 37)

39.3 (32.7, 45.9)

 

Geographic Zone

      

 Urban

1585 (64)

8.8

6.7 (5.4, 8.0)

20.8 (18.7, 22.9)

72.5 (70.2, 74.8)

 

 Rural

903 (36)

8.1

13.4 (11.1, 15.7)

23.1 (20.3, 26)

63.5 (60.2, 66.8)

<.0001

Neighborhood

 Mantica

668 (27)

8.1

6.4 (4.4, 8.3)

20.2 (17, 23.4)

73.5 (70.0, 76.9)

 

 Perla

975 (40)

8.5

9.0 (7.1, 10.8)

26.2 (23.3, 29.1)

64.8 (61.7, 67.9)

0.0039

 Sutiava

809 (33)

5.1

11.6 (9.3, 13.9)

17.6 (14.9, 20.3)

70.8 (67.6, 74.0)

 

Education

      

 No schooling

251 (10)

5.2

22.7 (17.4, 28)

21.8 (16.6, 27.1)

55.5 (49.1, 61.8)

 

 Primary

1020 (42)

7.5

12.0 (9.9, 14.1)

25.0 (22.3, 27.8)

63.0 (59.9, 66.1)

 

 Secondary

728 (30)

7.6

3.7 (2.3, 5.1)

18.3 (15.4, 21.2)

78.0 (74.9, 81.1)

<.0001

 University/Professional

451 (18)

7.3

3.6 (1.8, 5.4)

19.4 (15.6, 23.2)

77.0 (73.0, 81.1)

 

Poverty Index**

    

 Not Poor

1207(55)

7.5

7.5 (6.0, 9.0)

24 (21.6, 26.4)

68.5 (65.8, 71.1)

0.3308

 Poor

935(42)

7.7

7.9 (6.2, 9.6)

18.7 (16.2, 21.2)

73.5 (70.6, 76.3)

 

 Extremely poor

63(3)

14.3

9.3 (2.1, 16.4)

27.8 (16.7, 38.8)

63.0 (51.0, 74.9)

 

Water Source††

     

 Indoor Plumbing

1894 (86)

5.4

5.6 (4.6, 6.5)

17 (15.4, 18.5)

57.2 (55.2, 59.3)

 

 Community Source

198 (9)

0.5

1.1 (0.7, 1.6)

1.8 (1.2, 2.3)

5.5 (4.6, 6.5)

 

 Own well

414 (19)

1.5

2.9 (2.2, 3.7)

4.0 (3.2, 4.8)

10.1 (8.9, 11.4)

 

 Other

82 (4)

0.3

0.5 (0.2, 0.7)

0.6 (0.3, 1.0)

2.3 (1.7, 2.9)

 

Potential Risk Factors

      

Number of times drank unregulated alcohol (lija)

    

 None

2332 (95)

7.2

8.5 (7.4, 9.7)

21.8 (20, 23.5)

69.7 (67.7, 71.6)

0.0004

 ≥1 per week

121 (5)

8.3

20.7 (13.2, 28.3)

19.8 (12.4, 27.2)

59.5 (50.3, 68.6)

 

Number of cigarettes smoked

     

 None

2131 (87)

7.3

8.9 (7.6, 10.1)

21 (19.2, 22.8)

70.2 (68.2, 72.2)

0.0166

 ≥1 per day

322 (13)

6.8

11.0 (7.5, 14.5)

26.3 (21.3, 31.3)

62.7 (57.2, 68.1)

 

Self-reported diabetes

    

 No

2342 (95)

7.3

8.4 (7.3, 9.6)

21 (19.3, 22.7)

70.6 (68.7, 72.5)

<.0001

 Yes

111 (5)

7.2

24.3 (16, 32.6)

35.9 (26.7, 45.2)

39.8 (30.4, 49.3)

 

Self-reported high blood pressure

     

 No

2127 (87)

7.3

7.4 (6.2, 8.5)

20.6 (18.8, 22.4)

72.0 (70.1, 74.0)

<.0001

 Yes

326 (13)

6.7

20.7 (16.2, 25.3)

28.6 (23.5, 33.7)

50.7 (45, 56.3)

 

Number of years worked in agriculture

    

never

1365 (56)

7.0

4.5 (3.4, 5.6)

18.4 (16.2, 20.5)

77.1 (74.8, 79.5)

<.0001

 >0 to 4

325 (13)

8.6

6.7 (3.9, 9.6)

24.6 (19.7, 29.5)

68.7 (63.4, 74.0)

 

 5-9

201 (8)

7.0

9.6 (5.4, 13.9)

27.8 (21.4, 34.2)

62.6 (55.6, 69.5)

 

 10-14

187 (8)

4.3

15.6 (10.3, 21)

22.9 (16.7, 29.1)

61.5 (54.3, 68.6)

 

 ≥15

375 (15)

8.5

24.8 (20.2, 29.4)

27.4 (22.7, 32.1)

47.8 (42.5, 53.1)

 

Daily water consumption‡‡

   

 0-4

699 (29)

6.9

5.2 (3.5, 6.9)

17.8 (14.9, 20.8)

77 (73.7, 80.2)

<.0001

 5-8

808 (33)

7.3

7.9 (5.9, 9.8)

20.8 (17.9, 23.7)

71.3 (68.1, 74.5)

 

 9-12

505 (21)

7.9

12.5 (9.5, 15.5)

23.2 (19.4, 27.1)

64.3 (59.9, 68.7)

 

 13-52

439 (18)

7.1

13.7 (10.4, 17.1)

27.7 (23.4, 32.0)

58.6 (53.8, 63.4)

 
  1. *Prevalence was calculated as the number of participants in each eGFR by covariate strata, divided by the total number of participants in the relevant covariate strata. For example, the prevalence of females with eGFR < 60 was calculated as the number of females with eGFR < 60 divided by the total number of females in the study (i.e. 77/1324 = 5.8%).
  2. Percentages may not add up to 100 due to rounding.
  3. Calculated using the MDRD method [11] eGFR variable truncated at 150.
  4. §p-value for chi-square test of homogeneity.
  5. **Household-level relative poverty indicator calculated using data from health surveillance system that takes into consideration education level, occupation of each household member, water source, material predominantly used in home construction, and toilet facilities (see Additional file 1: Figure S1).
  6. ††Percentages do not add up to 100 because categories are not mutually exclusive.
  7. ‡‡Quartiles of ranked average number of glasses of water per day.