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Table 3 Significant associations between baseline clinical variables and biomarkers and change in short-term and long-term HRQOL scores, using univariate and multivariate analysis

From: Cardiac biomarkers and health-related quality of life in new hemodialysis patients without symptomatic cardiac disease

Characteristic Reference Unadjusted B coefficient 95% C.I. Adjusted B coefficient 95% C.I.
SF-36 Vitality
Change at 24 wks      
 High Hb Group Low Hb Group 5.09 1.16 to 9.03* 5.11 1.07 to 9.14*
 Platelet Count ≤ 260 × 109/L -5.00 -9.63 to -0.38* -4.99 -9.58 to -0.40*
Change at 48 wks      
 Urea reduction ratio ≤ 60% -6.97 -12.22 to -1.72** -7.06 -12.35 to 1.77**
 Serum calcium ≤ 2.42 mmol/L 5.34 0.94 to 9.73* 6.18 1.62 to 10.74**
 Platelet count ≤ 260 × 109/L -5.93 -10.67 to -1.18* -5.01 -9.84 to -0.18*
 Epo dose ≤ 6000 U/wk 5.25 1.07 to 9.43* 5.73 1.53 to 9.93**
Change at 96 wks      
 Fractional shortening Per 1% -0.32 -0.62 to -0.02*   
 Troponin T ≤ 0.051 ng/ml -7.55 -14.18 to -0.91* -7.09 -13.73 to -0.46*
SF-36 Physical functioning
Change at 24 wks      
 Left Ventricular Mass Index Per 1 g/m2 -0.06 -0.12 to -0.00*   
 Serum Calcium ≤ 2.42 mmol/L 4.25 0.02 to 8.47*   
 Platelet Count ≤ 260 × 109/L -5.54 -9.95 to -1/13 -5.93 -10.37 to -1.50**
Change at 48 wks      
 Serum Calcium ≤ 2.42 mmol/L 6.63 1.61 to 11.66** 6.00 0.39 to 11.62*
 Troponin T ≤ 0.051 ng/ml -6.40 -12.62 to -0.18* -6.70 -12.93 to -0.47*
Change at 96 wks      
 Diabetes No Diabetes -7.28 -14.07 to -0.49* -8.84 -16.61 to -1.07*
 Troponin T ≤ 0.051 ng/ml -9.43 -16.44 to -2.42**   
FACIT Fatigue      
Change at 24 wks      
 Lactase dehydrogenase Per 1 U/L -0.05 -0.09 to -0.00*   
 White blood cells ≤ 8.1 × 109/L -4.32 -8.19 to -0.46*   
 Troponin T ≤ 0.051 ng/ml -5.38 -9.37 to -1.38** -4.91 -9.09 to -0.74*
Change at 48 wks      
 Serum creatinine Per 1 umol/L 0.01 0.00 to 0.02** 0.01 0.00 to 0.02*
 Platelet Count ≤ 260 × 109/L -5.06 -9.20 to -0.93* -4.78 -8.92 to -0.63*
Change at 96 wks      
 Epo Dose ≤ 6000 U/wk -5.11 -9.92 to -0.31*   
  1. *p ≤ 0.05; **p ≤ 0.01.
  2. Unadjusted B coefficient was calculated using univariate linear regression (column 3 and 4).
  3. Adjusted B coefficient was calculated using multiple linear regression to identify the significant and independent predictors (column 5 and 6).