Cardiac biomarkers and health-related quality of life in new hemodialysis patients without symptomatic cardiac disease

Table 2 Significant associations between baseline clinical variables and biomarkers and baseline HRQOL scores, using univariate and multivariate analysis

Characteristic	Reference	Unadjusted B coefficient	95% C.I.	Adjusted B coefficient	95% C.I.
SF-36 Physical functioning
Female	Male	-7.56	-12.30 to -2.81**
Age	Per 1 year	-0.49	-0.63 to -0.35**	-0.38	-0.56 to -0.20**
Body Mass Index	Per 1 kg/m²	-0.63	-1.05 to -0.20**
Diabetes	No Diabetes	-8.25	-14.27 to -2.23**
Fistula	No Fistula	12.52	6.54 to 18.51**	10.69	3.52 to 17.86**
Serum Albumin	≤ 40 g/L	6.36	1.54 to 11.18**
Serum Creatinine	Per 1 umol/L	0.02	0.01 to 0.03**
Sodium	Per 1 mmol/L	0.76	0.06 to 1.46*
White Blood Cells	≤ 8.1 × 10⁹/L	-7.98	-13.60 to -2.37**
Neutrophils	≤ 68%	-7.33	-12.90 to -1.77**
Leptin	Per 1 ng/ml	-0.17	-0.26 to -0.08**
Troponin T	≤ 0.05 ng/ml	-9.54	-15.60 to -3.48**
NT-proBNP	≤ 651.9 pg/ml	-6.05	-12.11 to 0.01*	-6.33	-12.40 to -0.26*
IL-6	Per 1 pg/ml	-0.19	-0.38 to -0.01*
SF-36 Vitality
Female	Male	-5.73	-9.88 to -1.58**
Urea Reduction Ratio	≤ 60%	8.58	3.52 to 13.64**	6.33	0.48 to 12.17*
White Blood Cells	≤ 8.1 × 10⁹/L	-6.76	-11.62 to -1.91**
Leptin	Per 1 ng/ml	-0.09	-1.17 to -0.01*
C-reactive protein	Per 1 mg/L	-0.18	-0.35 to -0.00*
FACIT Fatigue
Female	Male	-5.00	-8.26 to -1.73**
Body Mass Index	Per 1 kg/m²	-0.30	-0.60 to 0.00*
Diabetes	No Diabetes	-5.07	-9.40 to -0.73*
Urea Reduction Rate	≤ 60%	6.75	3.04 to 10.47**	5.61	1.42 to 9.81**
Leptin	Per 1 ng/ml	-0.10	-0.17 to -0.04**

*p ≤ 0.05; **p ≤ 0.01.
Unadjusted B coefficient was calculated using univariate linear regression (column 3 and 4).
Adjusted B coefficient was calculated using multiple linear regression to identify the significant and independent predictors (column 5 and 6).

ISSN: 2054-3581