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Table 2 Significant associations between baseline clinical variables and biomarkers and baseline HRQOL scores, using univariate and multivariate analysis

From: Cardiac biomarkers and health-related quality of life in new hemodialysis patients without symptomatic cardiac disease

Characteristic Reference Unadjusted B coefficient 95% C.I. Adjusted B coefficient 95% C.I.
SF-36 Physical functioning
 Female Male -7.56 -12.30 to -2.81**   
 Age Per 1 year -0.49 -0.63 to -0.35** -0.38 -0.56 to -0.20**
 Body Mass Index Per 1 kg/m2 -0.63 -1.05 to -0.20**   
 Diabetes No Diabetes -8.25 -14.27 to -2.23**   
 Fistula No Fistula 12.52 6.54 to 18.51** 10.69 3.52 to 17.86**
 Serum Albumin ≤ 40 g/L 6.36 1.54 to 11.18**   
 Serum Creatinine Per 1 umol/L 0.02 0.01 to 0.03**   
 Sodium Per 1 mmol/L 0.76 0.06 to 1.46*   
 White Blood Cells ≤ 8.1 × 109/L -7.98 -13.60 to -2.37**   
 Neutrophils ≤ 68% -7.33 -12.90 to -1.77**   
 Leptin Per 1 ng/ml -0.17 -0.26 to -0.08**   
 Troponin T ≤ 0.05 ng/ml -9.54 -15.60 to -3.48**   
 NT-proBNP ≤ 651.9 pg/ml -6.05 -12.11 to 0.01* -6.33 -12.40 to -0.26*
 IL-6 Per 1 pg/ml -0.19 -0.38 to -0.01*   
SF-36 Vitality
 Female Male -5.73 -9.88 to -1.58**   
 Urea Reduction Ratio ≤ 60% 8.58 3.52 to 13.64** 6.33 0.48 to 12.17*
 White Blood Cells ≤ 8.1 × 109/L -6.76 -11.62 to -1.91**   
 Leptin Per 1 ng/ml -0.09 -1.17 to -0.01*   
 C-reactive protein Per 1 mg/L -0.18 -0.35 to -0.00*   
FACIT Fatigue      
 Female Male -5.00 -8.26 to -1.73**   
 Body Mass Index Per 1 kg/m2 -0.30 -0.60 to 0.00*   
 Diabetes No Diabetes -5.07 -9.40 to -0.73*   
 Urea Reduction Rate ≤ 60% 6.75 3.04 to 10.47** 5.61 1.42 to 9.81**
 Leptin Per 1 ng/ml -0.10 -0.17 to -0.04**   
  1. *p ≤ 0.05; **p ≤ 0.01.
  2. Unadjusted B coefficient was calculated using univariate linear regression (column 3 and 4).
  3. Adjusted B coefficient was calculated using multiple linear regression to identify the significant and independent predictors (column 5 and 6).