Assessment of potential biomarkers of subclinical vitamin K deficiency in patients with end-stage kidney disease

Elliott, Meghan J; Booth, Sarah L; Hopman, Wilma M; Holden, Rachel M

doi:10.1186/2054-3581-1-13

Canadian Journal of Kidney Health and Disease

Table 2 Cross-sectional correlations among measures of vitamin K status, demographic and biochemical variables

From: Assessment of potential biomarkers of subclinical vitamin K deficiency in patients with end-stage kidney disease

Variables		Phylloquinone		%ucOC		PIVKA-II
		r	p	r	p	r	p
Demographic variables
Age, years		0.108	0.49	0.063	0.69	0.37	0.015
Dialysis vintage, months		-0.25	0.11	0.06	0.72	-0.04	0.82
		*Mean ± SD*	p	*Mean ± SD*	p	*Mean ± SD*	p
Sex
Male		1.27 ± 1.23	0.91	25.4 ± 16.6	0.87	3.93 ± 2.47	0.98
Female		1.21 ± 1.08	0.91	22.9 ± 13.4	0.87	4.09 ± 2.66	0.98
Etiology of ESKD
Diabetes mellitus		1.13 ± 0.99	0.98	23.9 ± 16.8	0.93	4.11 ± 1.98	0.22
Renovascular disease		1.33 ± 1.34		25.5 ± 15.0		4.48 ± 3.10
Other		1.25 ± 1.19		24.3 ± 15.7		3.55 ± 2.35
Cardiovascular disease	Yes	1.15 + 1.01	0.72	19.8 ± 13.7	0.12	5.16 ± 3.26	0.009
	No	1.29 ± 1.25	0.72	26.9 ± 15.9	0.12	3.44 ± 1.90	0.009
Peripheral vascular disease	Yes	1.25 ± 1.36	0.52	23.2 ± 15.0	0.53	4.61 ± 2.73	0.08
	No	1.24 ± 1.06	0.52	25.4 ± 15.9	0.53	3.59 ± 2.33	0.08
Cerebrovascular disease	Yes	1.15 ± 1.15	0.84	16.0 ± 14.2	0.048	5.20 ± 3.93	0.58
	No	1.26 ± 1.19	0.84	26.0 ± 15.3	0.048	3.79 ± 2.22	0.58
History of fracture	Yes	0.94 ± 0.85	0.20	19.6 ± 14.8	0.035	4.08 ± 2.87	0.55
	No	1.44 ± 1.31	0.20	27.9 ± 15.1	0.035	3.93 ± 2.31	0.55
Smoking status	Current	0.55 ± 0.45	0.043	29.6 ± 20.0	0.55	3.74 ± 1.08	0.09
	Former	1.65 ± 1.47		24.2 ± 13.4		4.44 ± 2.51
	Never	1.12 ± 0.84		22.4 ± 15.4		3.59 ± 2.98
		r	p	r	p	r	p
Laboratory variables
Phosphate, mmol/L		-0.05	0.77	0.30	0.06	0.15	0.35
Calcium, ionized, mmol/L		0.15	0.33	0.22	0.18	0.08	0.63
Calcium-phosphate product, mmol²/L²		0.06	0.69	0.40	0.009	0.20	0.19
PTH, pmol/L		0.05	0.76	-0.26	0.10	-0.05	0.74
Albumin, g/L		-0.003	0.99	-0.07	0.66	-0.07	0.65
Total cholesterol, mmol/L		0.43	0.004	0.14	0.39	0.14	0.37
LDL cholesterol, mmol/L		0.17	0.30	0.22	0.18	0.21	0.19
HDL cholesterol, mmol/L		-0.04	0.82	0.26	0.10	-0.31	0.046
Triglycerides, mmol/L		0.45	0.002	-0.13	0.42	0.19	0.22
Kt/V		0.11	0.48	0.15	0.35	-0.33	0.027
URR		0.04	0.80	0.05	0.73	-0.06	0.68

ESKD, End-stage kidney disease; PTH, Parathyroid hormone; LDL, Low-density lipoprotein; HDL, High-density lipoprotein; Kt/V, measure of dialysis adequacy; URR, urea reduction ratio.

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ISSN: 2054-3581

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