Figure 2

Reduced nephron endowment in Sox4^nephron- kidneys. (a) Total glomerular number is significantly reduced in Sox4^nephron- kidneys (36%) compared to wild-type littermates at E17.5 (***p = 0.001; wild-type n = 4; Sox4^neprhon- n = 4). (b) Glomerular number is significantly reduced in a Sox4^nephron- kidneys (32%) compared to wild-type littermates at P7 (*p = 0.012; wild-type n = 3; Sox4^neprhon- n = 4).