Table 1 Characteristics of the study cohort stratified by sex and age categories

N %

39.5(1406)

60.5(2152)

40.0(7044)

60.0(10585)

42.9(3342)

57.1(4442)

Age (±SD)

35.5 ± 7.4

35.9 ± 7.2

0.1

63.4 ± 8.2

62.9 ± 8.3

<0.0001

81.0 ± 4.0

80.9 ± 4.0

0.5

Race

<0.0001

<0.0001

0.02

Caucasian

57.6(810)

65.1(1400)

70(4856)

74(7490)

77.8(2599)

80.6(3579)

Aboriginal

15.9(223)

10.3(222)

7.3(644)

4.8(635)

1.6(53)

1.1(51)

East Asian

6.8(95)

5.3(115)

5.1(359)

6.6(541)

7.8(260)

6.2(275)

Black

6.1(86)

5.4(116)

3.4(724)

2.8(1234)

9.2(306)

8.9(397)

South Asian

9.2(129)

9.3(201)

11.1(255)

9.1(345)

1.7(57)

1.3(58)

Other

4.5(63)

4.6(98)

3.1(206)

2.7(340)

2.0(67)

1.8(82)

BMI (±SD)

27.2 ± 8.6

26.9 ± 6.5

0.2

28.9 ± 8.1

27.9 ± 6.4

<0.0001

25.8 ± 6.1

25.4 ± 5.3

<0.0001

Distance to nearest dialysis facility in km (IQR)

11.4(5.0-62.2)

11.7(4.8-62.4)

0.7

12.0(4.9-59.5)

12.0(5.0-55.5)

0.9

8.6(4.0-28.8)

9.4(4.4-34.8)

0.06

Any pre-dialysis care % (N)

53.2(748)

50.9(1096)

0.2

58.5(4122)

58.7(6212)

0.8

57.2(1911)

59.2(2630)

0.07

Median number of days with pre-dialysis care (IQR)

562(220–1532)

574(211–1339)

0.9

133 (0–747)

140(0–812)

0.03

587 (217–1218)

666(246–1362)

0.003

Geographic region % (N)

0.08

0.06

0.2

Atlantic

9.2(129)

9.4(202)

11.6(815)

10.8(1137)

10.3(342)

10.4(461)

Central

19.3(685)

31.6(1122)

51.6(3626)

53.2(5618)

59.2(1969)

57.7(2558)

Prairie

12(425)

15.9(566)

24.3(1705)

23.2(2447)

17.6(586)

19.5(863)

Pacific

11.8(166)

12.0(258)

12.5(882)

12.9(1367)

13(431)

12.5(555)

Co-morbidities: % (N)

CAD

5.1(72)

5.6(120)

0.6

22.3(1572)

23.7(2508)

0.04

26.4(881)

29.1(1292)

0.008

AMI

3.4(48)

3.8(82)

0.6

19.4(1370)

25.2(2666)

<0.0001

22.9(765)

30.3(1344)

<0.0001

Pulmonary edema

14.4(202)

11.6(249)

0.02

29.5(2080)

26.8(2837)

<0.0001

32(1070)

30.5(1357)

0.2

DM

35.2(495)

36(774)

0.7

56.6(3984)

55.1(5932)

0.06

38.3(1279)

36.1(1602)

0.05

Stroke

3.8(54)

3.3(70)

0.4

14.0(988)

14.6(1541)

0.3

16.7(557)

19.5(865)

0.002

PVD

6.7(94)

6.7(144)

0.9

17.9(1263)

22.4(2370)

<0.0001

17.7(590)

23.8(1055)

<0.0001

Malignancy

3.4(48)

1.8(38)

0.002

10.7(757)

11.5(1217)

0.2

15(500)

21.5(957)

<0.0001

Lung disease

3.4(48)

2.3(49)

0.05

12.7(894)

11.5(1215)

0.02

12.1(405)

15.4(683)

<0.0001

HTN

71.3(1003)

77.6(1670)

<0.0001

83.3(5870)

83.2(8803)

0.8

84.4(2819)

82(3642)

0.006

Serious illness

9.7(136)

8.5(183)

0.3

11.3(794)

11.3(1198)

0.9

9.4(314)

9.8(437)

0.5

Current smoker

18.5(260)

22.6(487)

0.003

13.4(943)

15.8(1675)

<0.0001

5.3(176)

7(313)

0.001

CABG

2.6(36)

1.9(41)

0.2

10.6(748)

16.9(1794)

<0.0001

12.3(412)

20.5(909)

<0.0001

Number of co-morbidities (±SD)

1.8 ± 1.4

1.8 ± 1.3

0.4

3.0 ± 1.9

3.2 ± 1.9

<0.0001

2.9 ± 1.8

3.3 ± (1.9

<0.0001

Cause of ESRD % (N)

0.02

<0.0001

<0.0001

Vascular

6.9(97)

9.3(200)

17.2(1214)

18.3(1938)

39.3(1312)

39.3(1744)

DM

31.1(437)

31.4(676)

45.8(3227)

44.3(4694)

26.8(897)

25(1111)

GN

33.6(472)

31.9(687)

12.2(859)

13.7(1449)

8.7(291)

8.8(389)

Obstruction

4.6(64)

3.9(83)

2.2(153)

3.0(314)

2.4(81)

4.0(179)

Interstitial

1.6(22)

0.6(13)

1.3(94)

0.7(74)

1.6(53)

0.9(38)

PCKD

5.8(82)

5.3(114)

4.6(323)

4.2(445)

1.8(61)

1.6(73)

Other

7.8(109)

8.2(177)

8.6(607)

7.9(841)

6.5(217)

6.3(279)

Unknown

8.7(123)

9.4(202)

8.0(567)

7.8(830)

12.9(430)

14.2(629)

Serum Albumin g/L (±SD)

30.1 ± 10.5

31.5 ± 10.3

<0.0001

31.1 ± 9.5

31.8 ± 9.3

<0.0001

32.2 ± 8.8

32.2 ± 7.1

0.8

Hemoglobin g/L (±SD)

93.9 ± 26.7

97.1 ± 23.9

<0.0001

99.5 ± 32.2

100.3 ± 21.1

0.03

102.0 ± 25.3

102.7 ± 23.9

0.2

AVF/AVG % (N)

11.6(163)

17.3(372)

<0.0001

16.6(1168)

20.6(2181)

<0.0001

14.5(483)

18.9(838)

<0.0001