Fig. 2

Change in LV oxygen transport versus hematocrit (Hct) for control dogs (n = 5, open circle) at baseline, dobutamine-5 (5 μg/Kg/min; open triangle) and dobutamine-10 (10 μg/Kg/min; open square). Stage 1 CKD (n = 5, closed symbols and stage 2 CKD (n = 5, open dotted symbols) are shown. In control dogs, LV oxygen transport increased in direct relation to intravenous dobutamine levels. In dogs with Stage 1 or 2 CKD, maximal LV oxygen transport was achieved at the lower dose of intravenous dobutamine compared to controls. Data shown are means ± 1SD